REFERENCES - The Science of Evil: On Empathy and the Origins of Cruelty - Simon Baron-Cohen

The Science of Evil: On Empathy and the Origins of Cruelty - Simon Baron-Cohen (2011)


1. Baron-Cohen, S., Golan, O., Wheelwright, S., and Hill, J. J. Mindreading: The interactive guide to emotions. Jessica Kingsley, London, 2004.

2. Sapolsky, R. M. The trouble with testosterone and other essays on the human predicament. Scribner’s, New York, 1997.

3. Bogod, D. The Nazi hypothermia experiments: Forbidden data? Anaesthesia 59, 1155-1156 (2004).

4. Buergenthal, T. A lucky child : A memoir of surviving Auschwitz as a young boy. Profile, London, 2009.

5. Buber, M. I and thou, 2nd ed. Scribner’s, New York, 1958.

6. The Guardian, April 28, 2008.

7. Whose justice? BBC Newsnight, January 28, 2009.

8. Simonyan, A., and Arzumanyan, M. Soviet Armenian encyclopedia. National Academy of Sciences of Armenia, Yerevan, Armenia, 1981.

9. Taylor, D. Age 1-90: The victims of hidden war against women. The Guardian, December 5, 2008.

10. Davis, M. H. Empathy: A social psychological approach. Westview Press, Boulder, CO, 1994.

11. Leslie, A. Pretence and representation: The origins of “theory of mind.” Psychological Review 94, 412-426 (1987).

12. Baron-Cohen, S., and Wheelwright, S. The Empathy Quotient (EQ): An investigation of adults with Asperger Syndrome or high-functioning autism, and normal sex differences. Journal of Autism and Developmental Disorders 34, 163-175 (2004).

13. Billington, J., Baron-Cohen, S., and Wheelwright, S. Cognitive style predicts entry into physical sciences and humanities: Questionnaire and performance tests of empathy and systemizing. Learning and Individual Differences 17, 260-268 (2007).

14. Goldenfeld, N., Baron-Cohen, S., and Wheelwright, S. Empathizing and systemizing in males, females, and autism. Clinical Neuropsychiatry 2, 338-345 (2005).

15. Auyeung, B., Baron-Cohen, S., Wheelwright, S., Samarawickrema, N., Atkinson, M., and Satcher, M. The children’s Empathy Quotient (EQ-C) and Systemizing Quotient (SQ-C): Sex differences in typical development and in autism spectrum conditions. Journal of Autism and Developmental Disorders 39, 1509-1521 (2009).

16. Holliday-Willey, L. Pretending to be normal. Jessica Kingsley, London, 1999.

17. Baron-Cohen, S., The essential difference: Men, women, and the extreme male brain. London, Penguin, 2003.

18. Oakley, B., ed. Pathological altruism. Oxford University Press, Oxford, UK, 2011.

19. Frith, U., and Frith, C. Development and neurophysiology of mentalizing. Philosophical Transactions of the Royal Society 358, 459-473 (2003).

20. Amodio, D. M., and Frith, C. D. Meeting of minds: The medial frontal cortex and social cognition. Nature Reviews Neuroscience 7, 268-277 (2006).

21. Mitchell, J. P., Macrae, C. N., and Banaji, M. R. Dissociable medial prefrontal contributions to judgments of similar and dissimilar others. Neuron 50, 655-663 (2006).

22. Ochsner, K. N., Beer, J. S., Robertson, E. R., Cooper, J. C., Gabrieli, J. D., Kihsltrom, J. F., and D’Esposito, M. The neural correlates of direct and reflected self-knowledge. Neuroimage 28, 797-814 (2005).

23. Coricelli, G., and Nagel, R. Neural correlates of depth of strategic reasoning in medial prefrontal cortex. Proceedings of the National Academy of Sciences of the USA 106, 9163-9168 (2009).

24. Ochsner, K. N., Knierim, K., Ludlow, D. H., Hanelin, J., Ramachandran, T., Glover, G., and Mackey, S. C. Reflecting upon feelings: An fMRI study of neural systems supporting the attribution of emotion to self and other. Journal of Cognitive Neuroscience 16, 1746-1772 (2004).

25. Lombardo, M. V., Chakrabarti, B., Bullmore, E. T., Wheelwright, S. J., Sadek, S. A., Suckling, J., and Baron-Cohen, S. Shared neural circuits for mentalizing about the self and others. Journal of Cognitive Neuroscience 22, 1623-1635 (2010).

26. Jenkins, A. C., Macrae, C. N., and Mitchell, J. P. Repetition suppression of ventromedial prefrontal activity during judgments of self and others. Proceedings of the National Academy of Sciences of the USA 105, 4507-4512 (2008).

27. Moran, J. M., Macrae, C. N., Heatherton, T. F., Wyland, C. L., and Kelley, W. M. Neuroanatomical evidence for distinct cognitive and affective components of self. Journal of Cognitive Neuroscience 18, 1586-1594 (2006).

28. Damasio, A. Descartes’ error. Putnam, New York, 1994.

29. Sharot, T., Riccardi, A. M., Raio, C. M., and Phelps, E. A. Neural mechanisms mediating optimism bias. Nature 450, 102-105 (2007).

30. Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., and Kennedy, S. H. Deep brain stimulation for treatment-resistant depression. Neuron 45, 651-660 (2005).

31. Beer, J. S., Heerey, E. A., Keltner, D., Scabini, D., and Knight, R. T. The regulatory function of self-conscious emotion: Insights from patients with orbitofrontal damage. Journal of Personality and Social Psychology 85, 594-604 (2003).

32. Beer, J. S., John, O. P., Scabini, D., and Knight, R. T. Orbitofrontal cortex and social Journal of Cognitive Neuroscience 18, 871-879 (2006).

33. Shamay-Tsoory, S. G., Aharon-Peretz, J., and Perry, D. Two systems for empathy: A double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 132, 617-627 (2009).

34. Damasio, H., Grabowski, T., Frank, R., Galaburda, A. M., and Damasio, A. R. The return of Phineas Gage: Clues about the brain from the skull of a famous patient. Science 264, 1102-1105 (1994).

35. Macmillan, M. Restoring Phineas Gage: A 150th retrospective. Journal of the History of the Neurosciences 9, 46-66 (2000).

36. Baron-Cohen, S., Ring, H., Moriarty, J., Shmitz, P., Costa, D., and Ell, P. Recognition of mental state terms: A clinical study of autism, and a functional neuroimaging study of normal adults. British Journal of Psychiatry165, 640-649 (1994).

37. Stone, V., Baron-Cohen, S., and Knight, K. Frontal lobe contributions to theory of mind. Journal of Cognitive Neuroscience 10, 640-656 (1998).

38. Lamm, C., Nusbaum, H. C., Meltzoff, A. N., and Decety, J. What are you feeling? Using functional magnetic resonance imaging to assess the modulation of sensory and affective responses during empathy for pain. PLoS One 2, e1292 (2007).

39. Kumar, P., Waiter, G., Ahearn, T., Milders, M., Reid, I., and Steele, J. D. Frontal operculum temporal difference signals and social motor response learning. Human Brain Mapping 30, 1421-1430 (2008).

40. Calder, A. J., Lawrence, A. D., and Young, A. W. Neuropsychology of fear and loathing. Nature Reviews Neuroscience 2, 352-363 (2001).

41. Chakrabarti, B., Bullmore, E. T., and Baron-Cohen, S. Empathizing with basic emotions: Common and discrete neural substrates. Social Neuroscience 1, 364-384 (2006).

42. Hutchison, W. D., Davis, K. D., Lozano, A. M., Tasker, R. R., and Dostrovsky, J. O. Pain-related neurons in the human cingulate cortex. Nature Neuroscience 2, 403-405 (1999).

43. Craig, A. D. How do you feel—now? The anterior insula and human awareness. Nature Reviews Neuroscience 10, 59-70 (2009).

44. Singer, T., Seymour, B., O’Doherty, J., Kaube, H., Dolan, R. J., and Frith, C. D. Empathy for pain involves the affective but not sensory components of pain. Science 303, 1157-1167 (2004).

45. Jackson, P. L., Meltzoff, A. N., and Decety, J. How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage 24, 771-779 (2005).

46. Lamm, C., Batson, C. D., and Decety, J. The neural substrate of human empathy: Effects of perspective-taking and cognitive appraisal. Journal of Cognitive Neuroscience 19, 42-58 (2007).

47. Wicker, B., Keysers, C., Plailly, J., Royet, J. P., Gallese, V., and Rizzolatti, G. Both of us disgusted in my insula: The common neural basis of seeing and feeling disgust. Neuron 40, 655-664 (2003).

48. Singer, T., Seymour, B., O’Doherty, J. P., Stephan, K. E., Dolan, R. J., and Frith, C. D. Empathic neural responses are modulated by the perceived fairness of others. Nature 439, 466-469 (2006).

49. Carr, L. M., Iacoboni, M., Dubeau, M.-C., Mazziotta, J., and Lenzi, G. Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas. Proceedings of the National Academy of Sciences of the USA 100, 5497-5502 (2003).

50. Jabbi, M., Swart, M., and Keysers, C. Empathy for positive and negative emotions in the gustatory cortex. Neuroimage 34, 1744-1753 (2007).

51. Morrison, I., Lloyd, D., di Pellegrino, G., and Roberts, N. Vicarious responses to pain in the anterior cingulate cortex: Is empathy a multisensory issue? Cognitive, Affective, and Behavioral Neuroscience 4, 270-278 (2004).

52. Saxe, R., and Kanwisher, N. People thinking about thinking people: The role of the temporo-parietal junction in “theory of mind.” Neuroimage 19, 1835-1842 (2003).

53. Blanke, O., and Arzy, S. The out-of-body experience: Disturbed self-processing at the temporo-parietal junction. Neuroscientist 11, 16-24 (2005).

54. Arzy, S., Seeck, M., Ortigue, S., Spinelli, L., and Blanke, O. Induction of an illusory shadow person. Nature 443, 287 (2006).

55. Scholtz, J., Triantafyllou, C., Whitfield-Gabrieli, S., Brown, E. N., and Saxe, R. Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention. PLoS One 4, e4869 (2009).

56. Decety, J., and Lamm, C. The role of the right temporoparietal junction in social interaction: How low-level computational processes contribute to meta-cognition. Neuroscientist 13, 580-593 (2007).

57. Perrett, D. I., Penton-Voak, I. S., Little, A. C., Tiddeman, B. P., Burt, D. M., Schmidt, N., Oxley, R., Kinloch, N., and Barrett, L. Facial attractiveness judgements reflect learning of parental age characteristics. Proceedings of the Royal Society of London, Series B, 269, 873-880 (2002).

58. Campbell, R., Heywood, C., Cowey, A., Regard, M., and Landis, T. Sensitivity to eye gaze in prosopagnosic patients and monkeys with superior temporal sulcus ablation. Neuropsychologia 28, 1123-1142 (1990).

59. Baron-Cohen, S., Jolliffe, T., Mortimore, C., and Robertson, M. Another advanced test of theory of mind: Evidence from very high functioning adults with autism or Asperger Syndrome. Journal of Child Psychology and Psychiatry 38, 813-822 (1997).

60. Grossman, E. D., and Blake, R. Brain activity evoked by inverted and imagined biological motion. Vision Research 41, 1475-1482 (2001).

61. Keysers, C., Kaas, J. H., and Gazzola, V. Somatosensation in social perception. Nature Reviews Neuroscience 11, 417-428 (2010).

62. Keysers, C., Wicker, B., Gazzola, V., Anton, J. L., Fogassi, L., and Gallese, V. A touching sight: SII/PV activation during the observation and experience of touch. Neuron 42, 335-346 (2004).

63. Blakemore, S. J., Bristow, D., Bird, G., Frith, C., and Ward, J. Somatosensory activations during the observation of touch and a case of vision-touch synaesthesia. Brain 128, 1571-1583 (2005).

64. Ebisch, S. J., Perrucci, M. G., Ferretti, A., Del Gratta, C., Romani, G. L., and Gallese, V. The sense of touch: Embodied simulation in a visuotactile mirroring mechanism for observed animate or inanimate touch. Journal of Cognitive Neuroscience 20, 1611-1623 (2008).

65. Ishida, H., Nakajima, K., Inase, M., and Murata, A. Shared mapping of own and others’ bodies in visuotactile bimodal area of monkey parietal cortex. Journal of Cognitive Neuroscience 22, 83-96 (2010).

66. Banissy, M. J., and Ward, J. Mirror-touch synesthesia is linked with empathy. Nature Neuroscience 10, 815-816 (2007).

67. Bufalari, I., Aprile, T., Avenanti, A., Di Russo, F., and Aglioti, S. M. Empathy for pain and touch in the human somatosensory cortex. Cerebral Cortex 17, 2553-2561 (2007).

68. Adolphs, R., Damasio, H., Tranel, D., Cooper, G., and Damasio, A. R. A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping. Journal of Neuroscience 20, 2683-2690 (2000).

69. Pitcher, D., Garrido, L., Walsh, V., and Duchaine, B. C. Transcranial magnetic stimulation disrupts the perception and embodiment of facial expressions. Journal of Neuroscience 28, 8929-8933 (2008).

70. Cheng, Y., Lin, C. P., Liu, H. L., Hsu, Y. Y., Lim, K. E., Hung, D., and Decety, J. Expertise modulates the perception of pain in others. Current Biology 17, 1708-1713 (2007).

71. Rizzolatti, G., and Craighero, L. The mirror-neuron system. Annual Review in Neuroscience 27, 169-192 (2004).

72. Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., and Iacoboni, M. Understanding emotions in others: Mirror neuron dysfunction in children with autism spectrum disorders. Nature Neuroscience 9, 28-30 (2006).

73. Mukamel, R., Ekstrom, A. D., Kaplan, J., Iacoboni, M., and Fried, I. Single-neuron responses in humans during execution and observation of actions. Current Biology 20, 750-756 (2010).

74. Shepherd, S. V., Klein, J. T., Deaner, R. O., and Platt, M.L. Mirroring of attention by neurons in macaque parietal cortex. Proceedings of the National Academy of Sciences of the USA 106, 9489-9494 (2009).

75. Chartrand, T. L., and Bargh, J. A. The chameleon effect: The perception-behavior link and social interaction. Journal of Personality and Social Psychology 76, 893-910 (1999).

76. Zaki, J., Weber, J., Bolger, N., and Ochsner, K. The neural bases of empathic accuracy. Proceedings of the National Academy of Sciences of the USA 106, 11382-11387 (2009).

77. Schippers, M. B., Roebroeck, A., Renken, R., Nanetti, L., and Keysers, C. Mapping the information flow from one brain to another during gestural communication. Proceedings of the National Academy of Sciences of the USA 107, 9388-9393 (2010).

78. Lee, K. H., and Siegle, G. J. Common and distinct brain networks underlying explicit emotional evaluation: A meta-analytic study. Social, Cognitive, and Affective Neuroscience March 6 (2009), doi:10.1093 /scan/nsp001.

79. Wager, T. D., Davidson, M. L., Hughes, B. L., Lindquist, M. A., and Ochsner, K. N. Prefrontal-subcortical pathways mediating successful emotion regulation. Neuron 59, 1037-1050 (2008).

80. LeDoux, J. E. The emotional brain: The mysterious underpinnings of emotional life. Weidenfeld and Nicolson, London, 1998.

81. Everitt, B. J., Cardinal, R. N., Parkinson, J. A., and Robbins, T. W. Appetitive behavior : Impact of amygdala-dependent mechanisms of emotional learning. Annals of the New York Academy of Sciences 985, 233-250 (2003).

82. Johansen, J. P., Hamanaka, H., Monfils, M. H., Behnia, R., Deisseroth, K., Blair, H. T., and Ledoux, J. E. Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proceedings of the National Academy of Sciences of the USA 107, 12692-12697 (2010).

83. Baron-Cohen, S., Ring, H., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., and Williams, S. Social intelligence in the normal and autistic brain: An fMRI study. European Journal of Neuroscience 11, 1891-1898 (1999).

84. Adolphs, R., Tranel, D., Damasio, H., and Damasio, A. R. Fear and the human amygdala. Journal of Neuroscience 15, 5879-5891 (1995).

85. Spezio, M. L., Huang, P. Y., Castelli, F., and Adolphs, R. Amygdala damage impairs eye contact during conversations with real people. Journal of Neuroscience 27, 3994-3997 (2007).

86. Adolphs, R., Gosselin, F., Buchanan, T. W., Tranel, D., Schyns, P., and Damasio, A. R. A mechanism for impaired fear recognition after amygdala damage. Nature 433, 68-72 (2005).

87. Fletcher, P. C., Happe, F., Frith, U., Baker, S. C., Dolan, R. J., Frackowiak, R. S. J., and Frith, C. D. Other minds in the brain: A functional imaging study of “theory of mind” in story comprehension. Cognition 57, 109-128 (1995).

88. Saxe, R., and Powell, L. J. It’s the thought that counts: Specific brain regions for one component of theory of mind. Psychological Science 17, 692-699 (2006).

89. Gusnard, D. A., Akbudak, E., Shulman, G. L., and Raichle, M. E. Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function. Proceedings of the National Academy of Sciences of the USA 98, 4259-4264 (2001).

90. Johnson, S. C., Baxter, L. C., Wilder, L. S., Pipe, J. G., Heiserman, J. E., and Prigatano, G. P. Neural correlates of self-reflection. Brain 125, 1808-1814 (2002).

91. Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., and Heatherton, T. F. Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience 14, 785-794 (2002).

92. Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., and Panksepp, J. Self-referential processing in our brain—a meta-analysis of imaging studies on the self. Neuroimage 31, 440-457 (2006).

93. Kreisman, J. J., and Straus, H. I hate you—don’t leave me: Understanding the borderline personality. Avon Books, New York, 1989.

94. Johnson, C., Tobin, D., and Enright, A. Prevalence and clinical characteristics of borderline patients in an eating-disordered population. Journal of Clinical Psychiatry 50, 9-15 (1989).

95. Nace, E. P., Saxon, J. J. Jr., and Shore, N. A comparison of borderline and nonborderline alcoholic patients. Archives of General Psychiatry 40, 54-56 (1983).

96. Inman, D. J., Bascue, L. O., and Skoloda, T. Identification of borderline personality disorders among substance abuse inpatients. Journal of Substance Abuse Treatment 2, 229-232 (1985).

97. Soloff, P. H., Lis, J. A., Kelly, T., Cornelius, J., and Ulrich, R. Risk factors for suicidal behavior in borderline personality disorder. American Journal of Psychiatry 151, 1316-1323 (1994).

98. Zisook, S., Goff, A., Sledge, P., and Shuchter, S. R. Reported suicidal behavior and current suicidal ideation in a psychiatric outpatient clinic. Annals of Clinical Psychiatry 6, 27-31 (1994).

99. Isomesta, E. T., Henriksson, M. M., Heikkinen, M. E., Aro, H. M., Marttunen, M. J., Kuoppasalmi, K. I., and Lonnqvist, J. K. Suicide among subjects with personality disorders. American Journal of Psychiatry 153, 667-673 (1996).

100. Runeson, B. Mental disorder in youth suicide: DSM-III-R Axes I and II. Acta Psychiatrica Scandinavica 79, 490-497 (1989).

101. Paris, J., and Zweig-Frank, H. A 27-year follow-up of patients with borderline personality disorder. Comprehensive Psychiatry 42, 482-487 (2001).

102. Stone, M. H., Stone, D. K., and Hurt, S. W. Natural history of borderline patients treated by intensive hospitalization. Psychiatric Clinics of North America 10, 185-206 (1987).

103. Rosten, N. Marilyn, an untold story. New American Library, New York, 1973.

104. Gunderson, J. G., Kerr, J., and Englund, D. W. The families of borderlines: A comparative study. Archives of General Psychiatry 37, 27-33 (1980).

105. Frank, H., and Paris, J. Recollections of family experience in borderline patients. Archives of General Psychiatry 38, 1031-1034 (1981).

106. Ogata, S. N., Silk, K. R., Goodrich, S., Lohr, N. E., Westen, D., and Hill, E. M. Childhood sexual and physical abuse in adult patients with borderline personality disorder. American Journal of Psychiatry 147, 1008-1013 (1990).

107. Paris, J., Zweig-Frank, H., and Guzder, J. Risk factors for borderline personality in male outpatients. Journal of Nervous and Mental Disease 182, 375-380 (1994).

108. Zanarini, M. C. Childhood experiences associated with the development of borderline personality disorder. Psychiatric Clinics of North America 23, 89-101 (2000).

109. Zweig-Frank, H., Paris, J., and Guzder, J. Psychological risk factors for dissociation and self-mutilation in female patients with borderline personality disorder. Canadian Journal of Psychiatry 39, 259-264 (1994).

110. Yen, S., Zlotnick, C., and Costello, E. Affect regulation in women with borderline personality disorder traits. Journal of Nervous and Mental Disease 190, 693-696 (2002).

111. Bandelow, B., Krause, J., Wedekind, D., Broocks, A., Hajak, G., and Ruther, E. Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls. Psychiatry Research 134, 169-179 (2005).

112. New, A. S., Triebwasser, J., and Charney, D. S. The case for shifting borderline personality disorder to Axis I. Biological Psychiatry 64, 653-659 (2008).

113. Paris, J., Nowlis, D., and Brown, R. Developmental factors in the outcome of borderline personality disorder. Comprehensive Psychiatry 29, 147-150 (1988).

114. Bryer, J. B., Nelson, B. A., Miller, J. B., and Krol, P. A. Childhood sexual and physical abuse as factors in adult psychiatric illness. American Journal of Psychiatry 144, 1426-1430 (1987).

115. Soloff, P. H., Price, J. C., Meltzer, C. C., Fabio, A., Frank, G. K., and Kaye, W. H. 5HT2A receptor binding is increased in borderline personality disorder. Biological Psychiatry 62, 580-587 (2007).

116. Snyder, S., and Pitts, W. M. Jr. Electroencephalography of DSM-III borderline personality disorder. Acta Psychiatrica Scandinavica 69, 129-134 (1984).

117. Soloff, P. H., Kelly, T. M., Strotmeyer, S. J., Malone, K. M., and Mann, J. J. Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. Psychiatry Research 119, 11-24 (2003).

118. Siever, L. J., Buchsbaum, M. S., New, A. S., Spiegel-Cohen, J., Wei, T., Hazlett, E. A., Sevin, E., Nunn, M., and Mitropoulou, V. d,l-fenfluramine response in impulsive personality disorder assessed with [18F] fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology 20, 413-423 (1999).

119. Soloff, P. H., Meltzer, C. C., Greer, P. J., Constantine, D., and Kelly, T. M. A fenfluramine-activated FDG-PET study of borderline personality disorder. Biological Psychiatry 47, 540-547 (2000).

120. Arango, V., Underwood, M. D., Gubbi, A. V., and Mann, J. J. Localized alterations in pre-and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research 688, 121-133 (1995).

121. Stockmeier, C. A., Dilley, G. E., Shapiro, L. A., Overholser, J. C., Thompson, P. A., and Meltzer, H. Y. Serotonin receptors in suicide victims with major depression. Neuropsychopharmacology 16, 162-173 (1997).

122. Juengling, F. D., Schmahl, C., Hesslinger, B., Ebert, D., Bremner, J. D., Gostomzyk, J., Bohus, M., and Lieb, K. Positron emission tomography in female patients with borderline personality disorder. Journal of Psychiatric Research 37, 109-115 (2003).

123. Herpertz, S. C., Dietrich, T. M., Wenning, B., Krings, T., Erberich, S. G., Willmes, K., Thron, A., and Sass, H. Evidence of abnormal amygdala functioning in borderline personality disorder: A functional MRI study. Biological Psychiatry 50, 292-298 (2001).

124. Donegan, N. H., Sanislow, C. A., Blumberg, H. P., Fulbright, R. K., Lacadie, C., Skudlarski, P., Gore, J. C., Olson, I. R., McGlashan, T. H., and Wexler, B. E. Amygdala hyperreactivity in borderline personality disorder: Implications for emotional dysregulation. Biological Psychiatry 54, 1284-1293 (2003).

125. King-Casas, B., Sharp, C., Lomax-Bream, L., Lohrenz, T., Fonagy, P., and Montague, P. R. The rupture and repair of cooperation in borderline personality disorder. Science 321, 806-810 (2008).

126. Brambilla, P., Soloff, P. H., Sala, M., Nicoletti, M. A., Keshavan, M. S., and Soares, J. C. Anatomical MRI study of borderline personality disorder patients. Psychiatry Research 131, 125-133 (2004).

127. Driessen, M., Herrmann, J., Stahl, K., Zwaan, M., Meier, S., Hill, A., Osterheider, M., and Petersen, D. Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry 57, 1115-1122 (2000).

128. Rusch, N., van Elst, L. T., Ludaescher, P., Wilke, M., Huppertz, H. J., Thiel, T., Schmahl, C., Bohus, M., Lieb, K., Hesslinger, B., Hennig, J., and Ebert, D. A voxelbased morphometric MRI study in female patients with borderline personality disorder. Neuroimage 20, 385-392 (2003).

129. Tebartz van Elst, L., Hesslinger, B., Thiel, T., Geiger, E., Haegele, K., Lemieux, L., Lieb, K., Bohus, M., Hennig, J., and Ebert, D. Frontolimbic brain abnormalities in patients with borderline personality disorder: A volumetric magnetic resonance imaging study. Biological Psychiatry 54, 163-171 (2003).

130. Soloff, P. H., Fabio, A., Kelly, T. M., Malone, K. M., and Mann, J. J. High-lethality status in patients with borderline personality disorder. Journal of Personality Disorders 19, 386-399 (2005).

131. Fertuck, E. A., Jekal, A., Song, I., Wyman, B., Morris, M. C., Wilson, S. T., Brodsky, B. S., and Stanley, B. Enhanced “Reading the Mind in the Eyes” in borderline personality disorder compared to healthy controls. Psychological Medicine 39, 1979-1988 (2009).

132. Fertuck, E. A., Lenzenweger, M. F., Clarkin, J. F., Hoermann, S., and Stanley, B. Executive neurocognition, memory systems, and borderline personality disorder. Clinical Psychology Review 26, 346-375 (2006).

133. Shamay-Tsoory, S. G., Tibi-Elhanany, Y., and Aharon-Peretz, J. The green-eyed monster and malicious joy: The neuroanatomical bases of envy and gloating (schadenfreude). Brain 130, 1663-1678 (2007).

134. American Psychiatric Association, DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. American Psychiatric Association, Washington, DC, 1994.

135. Fazel, S., and Danesh, J. Serious mental disorder in 23,000 prisoners: A systematic review of 62 surveys. Lancet 359, 545-550 (2002).

136. Hart, S. D. and Hare, R. D. Psychopathy and antisocial personality disorder. Current Opinion in Psychiatry 9, 129-132 (1996).

137. Cleckley, H. M. The mask of sanity: An attempt to clarify some issues about the so-called psychopathic personality, rev. ed. Mosby Medical Library, St. Louis, 1982.

138. Babiak, P., and Hare, R. D. Snakes in suit: When psychopaths go to work. Regan Books, New York, 2007.

139. Christie, R., and Geis, F. L. Studies in Machiavellianism. Academic Press, New York, 1970.

140. Rutter, M. Psychosocial resilience and protective mechanisms. American Journal of Orthopsychiatry 57, 316-331 (1987).

141. Bowlby, J. Attachment. Basic Books, New York, 1969.

142. Saltaris, C. Psychopathy in juvenile offenders: Can temperament and attachment be considered as robust developmental precursors? Clinical Psychology Reviews 22, 729-752 (2002).

143. DeKlyen, M., Speltz, M. L., and Greenberg, M. T. Fathering and early onset conduct problems: Positive and negative parenting, father-son attachment, and the marital context. Clinical Child and Family Psychology Review1, 3-21 (1998).

144. Harlow, H., and Zimmerman, R. Affectionless responses in the infant monkey. Scientific American 130, 421-432 (1959).

145. Hinde, R. A., and Spencer-Booth, Y. Effects of brief separation from mother on rhesus monkeys. Science 173, 111-118 (1971).

146. Bowlby, J. Maternal care and mental health. World Health Organization, Geneva, 1951.

147. Harris, P. Children and emotions. Blackwell, London, 1989.

148. Marshall, L. A., and Cooke, D. J. The childhood experiences of psychopaths: A retrospective study of familial and societal factors. Journal of Personality Disorders 13, 211-225 (1999).

149. Fonagy, P. Attachment and borderline personality disorder. Journal of the American Psychoanalytical Association 48, 1129-1146; discussion 1175-1187 (2000).

150. Baumrind, D. Rejoinder to Lewis’ reinterpretation of parental firm control effects: Are authoritative families really harmonious? Psychological Bulletin 94, 132-142 (1983).

151. Davis, M. H. Measuring individual differences in empathy: Evidence for a multidimensional approach. Journal of Personality and Social Psychology 44, 113-126 (1983).

152. Blair, R. J. R. Responsiveness to distress cues in the child with psychopathic tendencies. Personality and Individual Differences 27, 135-145 (1999).

153. Blair, R. J. R. Moral reasoning in the child with psychopathic tendencies. Personality and Individual Differences 22, 731-739 (1997).

154. Blair, R. J. R., and Coles, M. Expression recognition and behavioral problems in early adolescence. Cognitive Development 15, 421-434 (2000).

155. Stevens, D., Charman, T., and Blair, R. J. Recognition of emotion in facial expressions and vocal tones in children with psychopathic tendencies. Journal of Genetic Psychology 162, 201-211 (2001).

156. Lorenz, A. R., and Newman, J. P. Deficient response modulation and emotion processing in low-anxious Caucasian psychopathic offenders: Results from a lexical decision task. Emotion 2, 91-104 (2002).

157. Williamson, S., Harpur, T. J., and Hare, R. D. Abnormal processing of affective words by psychopaths. Psychophysiology 28, 260-273 (1991).

158. Dodge, K. A. Social-cognitive mechanisms in the development of conduct disorder and depression. Annual Review of Psychology 44, 559-584 (1993).

159. Lee, M., and Prentice, N. M. Interrelations of empathy, cognition, and moral reasoning with dimensions of juvenile delinquency. Journal of Abnormal Child Psychology 16, 127-139 (1988).

160. Smetana, J. G., and Braeges, J. L. The development of toddlers’ moral and conventional judgments. Merrill-Palmer Quarterly 36, 329-346 (1990).

161. Dunn, J., and Hughes, C. “I got some swords and you’re dead!”: Violent fantasy, antisocial behavior, friendship, and moral sensibility in young children. Child Development 72, 491-505 (2001).

162. Gray, J. A. The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system. Clarendon Press, Oxford, UK, 1982.

163. Newman, J. P. Response perseveration in psychopaths. In Psychopathy: Theory, research, and implications for society, ed. D. J. Cooke, A. E. Forth, and R. D. Hare. Kluwer, Dordrecht, Netherlands, 1998, 81-104.

164. Newman, J. P., Patterson, C. M., and Kosson, D. S. Response perseveration in psychopaths. Journal of Abnormal Psychology 96, 145-148 (1987).

165. Hoffman, M. L. Discipline and internalization. Developmental Psychology 30, 26-28 (1994).

166. Verona, E., Patrick, C. J., and Joiner, T. E. Psychopathy, antisocial personality, and suicide risk. Journal of Abnormal Psychology 110, 462-470 (2001).

167. Lykken, D. T. A study of anxiety in the sociopathic personality. Journal of Abnormal and Social Psychology 55, 6-10 (1957).

168. Flor, H., Birbaumer, N., Hermann, C., Ziegler, S., and Patrick, C. J. Aversive Pavlovian conditioning in psychopaths: Peripheral and central correlates. Psychophysiology 39, 505-518 (2002).

169. Levenston, G. K., Patrick, C. J., Bradley, M. M., and Lang, P. J. The psychopath as observer: Emotion and attention in picture processing. Journal of Abnormal Psychology 109, 373-385 (2000).

170. Volkow, N. D., and Tancredi, L. Neural substrates of violent behaviour: A preliminary study with positron emission tomography. British Journal of Psychiatry 151, 668-673 (1987).

171. Soderstrom, H., Hultin, L., Tullberg, M., Wikkelso, C., Ekholm, S., and Forsman, A. Reduced frontotemporal perfusion in psychopathic personality. Psychiatry Research 114, 81-94 (2002).

172. Craig, M. C., Catani, M., Deeley, Q., Latham, R., Daly, E., Kanaan, R., Picchioni, M., McGuire, P. K., Fahy, T., and Murphy, D. G. Altered connections on the road to psychopathy. Molecular Psychiatry 14, 946-953 (2009).

173. Raine, A., Yang, Y., Narr, K. L., and Toga, A. W. Sex differences in orbitofrontal gray matter as a partial explanation for sex differences in antisocial personality. Molecular Psychiatry (2009), doi:10.1038/mp.2009.136.

174. Damasio, A. R., Tranel, D., and Damasio, H. Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behavioral Brain Research 41, 81-94 (1990).

175. Damasio, A. R., Tranel, D., and Damasio, H. C. Somatic markers and the guidance of Frontal lobe function and dysfunction , ed. H. S. Levin, H. M. Eisenberg, and A. L. Benton. Oxford University Press, New York, 1991, 217-229.

176. Krajbich, I., Adolphs, R., Tranel, D., Denburg, N. L., and Camerer, C. F. Economic games quantify diminished sense of guilt in patients with damage to the prefrontal cortex. Journal of Neuroscience 29, 2188-2192 (2009).

177. Koenigs, M., Young, L., Adolphs, R., Tranel, D., Cushman, F., Hauser, M., and Damasio, A. Damage to the prefrontal cortex increases utilitarian moral judgments. Nature 446, 908-911 (2007).

178. Young, L., Bechara, A., Tranel, D., Damasio, H., Hauser, M., and Damasio, A. Damage to ventromedial prefrontal cortex impairs judgment of harmful intent. Neuron 65, 845-851 (2010).

179. Heims, H. C., Critchley, H. D., Dolan, R., Mathias, C. J., and Cipolotti, L. Social and motivational functioning is not critically dependent on feedback of autonomic responses: Neuropsychological evidence from patients with pure autonomic failure. Neuropsychologia 42, 1979-1988 (2004).

180. Raine, A., Buchsbaum, M., and LaCasse, L. Brain abnormalities in murderers indicated by positron emission tomography. Biological Psychiatry 42, 495-508 (1997).

181. Raine, A., Lencz, T., Bihrle, S., LaCasse, L., and Colletti, P. Reduced prefrontal gray matter volume and reduced autonomic activity in antisocial personality disorder. Archives of General Psychiatry 57, 119-127; discussion 128-129 (2000).

182. Goyer, P. F., Andreason, P. J., Semple, W. E., Clayton, A. H., King, A. C., Compton-Toth, B. A., Schulz, S. C., and Cohen, R. M. Positron-emission tomography and personality disorders. Neuropsychopharmacology 10, 21-28 (1994).

183. Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Benning, S. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E., Cole, D., Kessler, R. M., and Zald, D. H. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nature Neuroscience 13, 419-421 (2010).

184. Young, L., Camprodon, J. A., Hauser, M., Pascual-Leone, A., and Saxe, R. Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments. Proceedings of the National Academy of Sciences of the USA 107, 6753-6758 (2010).

185. Young, L., Cushman, F., Hauser, M., and Saxe, R. The neural basis of the interaction between theory of mind and moral judgment. Proceedings of the National Academy of Sciences of the USA 104, 8235-8240 (2007).

186. Decety, J., Michalska, K. J., Akitsuki, Y., and Lahey, B. B. Atypical empathic responses in adolescents with aggressive conduct disorder: A functional MRI investigation. Biological Psychology 80, 203-211 (2009).

187. Veit, R., Flor, H., Erb, M., Hermann, C., Lotze, M., Grodd, W., and Birbaumer, N. Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neuroscience Letters 328, 233-236 (2002).

188. Bremner, J. D., Randall, P., Scott, T. M., Capelli, S., Delaney, R., McCarthy, G., and Charney, D. S. Deficits in short-term memory in adult survivors of childhood abuse. Psychiatry Research 59, 97-107 (1995).

189. Panksepp, J. Affective neuroscience: The foundations of human and animal emotions. Oxford University Press, New York, 1998.

190. Jacobson, L., and Sapolsky, R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocrine Reviews 12, 118-134 (1991).

191. McEwen, B. S., Angulo, J., Cameron, H., Chao, H. M., Daniels, D., Gannon, M. N., Gould, E., Mendelson, S., Sakai, R., Spencer, R. et al., Paradoxical effects of adrenal steroids on the brain: Protection versus degeneration. Biological Psychiatry 31, 177-199 (1992).

192. Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., and Chattarji, S. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. Journal of Neuroscience 22, 6810-6818 (2002).

193. Drevets, W. C. Neuroimaging abnormalities in the amygdala in mood disorders. Annals of the New York Academy of Sciences 985, 420-444 (2003).

194. Hettema, J. M., Neale, M. C., and Kendler, K. S. A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry 158, 1568-1578 (2001).

195. Blair, R. J. R., Mitchell, D., and Blair, K. The psychopath: Emotion and the brain. Blackwell, Oxford, UK, 2005.

196. Stone, M. H. Normal narcissism: An etiological and ethological perspective. In Disorders of narcissism: Diagnostic, clinical, and empirical implications, ed. E. F. Ronningstram. American Psychiatric Press, Washington, DC, 1997, 7-28.

197. Cooper, A. M. Further developments in the clinical diagnosis of narcissistic personality disorder. In Disorders of narcissism: Diagnostic, clinical, and empirical implications , ed. E. F. Ronningstram. American Psychiatric Press, Washington, DC, 1997, 53-74.

198. Schlesinger, L. Pathological narcissism and serial homicide: Review and case study. Current Psychology 17, 212-221 (1997).

199. Di Martino, A., Ross, K., Uddin, L. Q., Sklar, A. B., Castellanos, F. X., and Milham, M. P. Functional brain correlates of social and nonsocial processes in autism spectrum disorders: An activation likelihood estimation meta-analysis. Biological Psychiatry 65, 63-74 (2009).

200. Lombardo, M. V., Baron-Cohen, S., Belmonte, M. K., and Chakrabarti, B. Neural endophenotypes of social behavior in autism spectrum conditions. In Handbook of Social Neuroscience, ed. J. Decety and J. Cacioppo. Oxford University Press, Oxford, UK, in press.

201. Happé, F., Ehlers, S., Fletcher, P., Frith, U., Johansson, M., Gillberg, C., Dolan, R., Frackowiak, R., and Frith, C. “Theory of mind” in the brain: Evidence from a PET scan study of Asperger Syndrome. Neuroreport 8, 197-201 (1996).

202. Wang, A. T., Lee, S. S., Sigman, M., and Dapretto, M. Neural basis of irony comprehension in children with autism: The role of prosody and context. Brain 129, 932-943 (2006).

203. Wang, A. T., Lee, S. S., Sigman, M., and Dapretto, M. Reading affect in the face and voice: Neural correlates of interpreting communicative intent in children and adolescents with autism spectrum disorders. Archives of General Psychiatry 64, 698-708 (2007).

204. Baron-Cohen, S., and Hammer, J. Parents of children with Asperger Syndrome: What is the cognitive phenotype? Journal of Cognitive Neuroscience 9, 548-554 (1997).

205. Baron-Cohen, S., Wheelwright, S., Hill, J., Raste, Y., and Plumb, I. The “Reading the Mind in the Eyes” test revised version: A study with normal adults, and adults with Asperger Syndrome or high-functioning autism. Journal of Child Psychology and Psychiatry 42, 241-252 (2001).

206. Pelphrey, K. A., Morris, J. P., and McCarthy, G. Neural basis of eye gaze processing deficits in autism. Brain 128, 1038-1048 (2005).

207. Herrington, J. D., Baron-Cohen, S., Wheelwright, S., Brammer, M., Singh, K. D., Bullmore, E. T., and Williams, S. C. R. The role of MT+ /V5 during biological motion perception in Asperger Syndrome: An fMRI study. Research in Autism Spectrum Disorders 1, 14-27 (2007).

208. Pierce, K., Muller, R.-A., Ambrose, J., Allen, G., and Courchesne, E. Face processing occurs outside the “fusiform face area” in autism: Evidence from functional MRI. Brain 124, 2059-2073 (2001).

209. Wang, A. T., Dapretto, M., Hariri, A. R., Sigman, M., and Bookheimer, S.Y. Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry 43, 481-490 (2004).

210. Ashwin, C., Baron-Cohen, S., O’Riordan, M., Wheelwright, S., and Bullmore, E. T. Differential activation of the amygdala and the “social brain” during fearful face-processing in Asperger Syndrome. Neuropsychologia45, 2-14 (2007).

211. Corbett, B. A., Constantine, L. J., Hendren, R., Rocke, D., and Ozonoff, S. Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder, and typical development. Psychiatry Research 166, 210-222 (2009).

212. Critchley, H. D., Daly, E. M., Bullmore, E. T., Williams, S. C. R., Van Amelsvoort, T., Robertson, D. M., Rowe, A., Phillips, M., McAlonan, G., Howlin, P., and Murphy, D.G. The functional neuroanatomy of social behaviour: Changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain 123, 2203-2212 (2000).

213. Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., and Davidson, R. J. Gaze fixation and the neural circuitry of face processing in autism. Nature Neuroscience 10, 1-8 (2005).

214. Grezes, J., Wicker, B., Berthoz, S., and de Gelder, B. A failure to grasp the affective meaning of actions in autism spectrum disorder subjects. Neuropsychologia 47, 1816-1825 (2009).

215. Pelphrey, K. A., Morris, J. P., McCarthy, G., and Labar, K. S. Perception of dynamic changes in facial affect and identity in autism. Social, Cognitive, and Affective Neuroscience 2, 140-149 (2007).

216. Dinstein, I., Thomas, C., Humphreys, K., Minshew, N., Behrmann, M., and Heeger, D. J. Normal movement selectivity in autism. Neuron 66, 461-469 (2010).

217. Southgate, V., and Hamilton, A. F. Unbroken mirrors: Challenging a theory of autism. Trends in Cognitive Sciences 12, 225-229 (2008).

218. Abell, F., Happé, F., and Frith, U. Do triangles play tricks? Attribution of mental states to animated shapes in normal and abnormal development. Cognitive Development 15, 1-16 (2000).

219. Castelli, F., Frith, C., Happé, F., and Frith, U. Autism, Asperger Syndrome, and brain mechanisms for the attribution of mental states to animated shapes. Brain 125, 1839-1849 (2002).

220. Kana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., and Just, M. A. Atypical frontal-posterior synchronization of theory of mind regions in autism during mental state attribution. Social Neuroscience 4, 135-152 (2009).

221. Hill, E., Berthoz, S., and Frith, U. Brief report: Cognitive processing of own emotions in individuals with autistic spectrum disorder and in their relatives. Journal of Autism and Developmental Disorders 34, 229-235 (2004).

222. Lombardo, M. V., and Baron-Cohen, S. Unraveling the paradox of the autistic self. Wiley Interdisciplinary Reviews: Cognitive Science 1, 393-403 (2010).

223. Lombardo, M.V., Barnes, J. L., Wheelwright, S., and Baron-Cohen, S. Self-referential cognition and empathy in autism. PLoS 2, e883 (2007).

224. Williams, D. M., and Happe, F. What did I say? Versus what did I think? Attributing false beliefs to self amongst children with and without autism. Journal of Autism and Developmental Disorders 39, 865-873 (2009).

225. Silani, G., Bird, G., Brindley, R., Singer, T., Frith, C., and Frith, U. Levels of emotional awareness and autism: An fMRI study. Social Neuroscience 3, 97-112 (2008).

226. Ernst, M., Zametkin, A. J., Matochik, J. A., Pascualvaca, D., and Cohen, R. M. Low medial prefrontal dopaminergic activity in autistic children. Lancet 350, 638 (1997).

227. Murphy, D. G., Daly, E., Schmitz, N., Toal, F., Murphy, K., Curran, S., Erlandsson, K., Eersels, J., Kerwin, R., Ell, P., and Travis, M. Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger’s Syndrome: An in vivo SPECT study. American Journal of Psychiatry 163, 934-936 (2006).

228. Haznedar, M. M., Buchsbaum, M. S., Wei, T. C., Hof, P. R., Cartwright, C., Bienstock, C. A., and Hollander, E. Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. American Journal of Psychiatry 157, 1994-2001 (2000).

229. Ohnishi, T., Matsuda, H., Hashimoto, T., Kunihiro, T., Nishikawa, M., Uema, T., and Sasaki, M. Abnormal regional cerebral blood flow in childhood autism. Brain 123, 1838-1844 (2000).

230. Kennedy, D. P., and Courchesne, E. The intrinsic functional organization of the brain is altered in autism. Neuroimage 39, 1877-1885 (2008).

231. Kennedy, D. P., Redcay, E., and Courchesne, E. Failing to deactivate: Resting functional abnormalities in autism. Proceedings of the National Academy of Sciences of the USA 103, 8275-8280 (2006).

232. Lombardo, M. V., Chakrabarti, B., Bullmore, E. T., Sadek, S. A., Pasco, G., Wheelwright, S. J., Suckling, J., and Baron-Cohen, S. Atypical neural self-representation in autism. Brain 133, 611-624 (2010).

233. Minio-Paluello, I., Baron-Cohen, S., Avenanti, A., Walsh, V., and Aglioti, S. M. Absence of embodied empathy during pain observation in Asperger Syndrome. Biological Psychiatry 65, 55-62 (2009).

234. Tomlin, D., Kayali, M. A., King-Casas, B., Anen, C., Camerer, C. F., Quartz, S. R., and Montague, P. R. Agent-specific responses in the cingulate cortex during economic exchanges. Science 312, 1047-1050 (2006).

235. Frith, C. D., and Frith, U. The self and its reputation in autism. Neuron 57, 331-332 (2008).

236. Chiu, P. H., Kayali, M. A., Kishida, K. T., Tomlin, D., Klinger, L. G., Klinger, M. R., and Montague, P. R. Self responses along cingulate cortex reveal quantitative neural phenotype for high-functioning autism. Neuron 57, 463-473 (2008).

237. Lombardo, M. V., Chakrabarti, B., Bullmore, E. T., Consortium, M. A., and Baron-Cohen, S. Atypical neural mechanisms for mentalizing about self and other in autism. Archives of General Psychiatry (under review).

238. Baron-Cohen, S., Ashwin, E., Ashwin, C., Tavassoli, T., and Chakrabarti, B. Talent in autism: Hyper-systemizing, hyper-attention to detail, and sensory hypersensitivity. Philosophical Transactions of the Royal Society of London B. Biological Sciences 364, 1377-1383 (2009).

239. Baron-Cohen, S. The hyper-systemizing, assortative mating theory of autism. Progress in Neuropsychopharmacology and Biological Psychiatry 30, 865-872 (2006).

240. Tammet, D. Born on a blue day. Hodder and Stoughton, London, 2006.

241. Baron-Cohen, S., Bor, D., Billington, J., Asher, J., Wheelwright, S., and Ashwin, C. Savant memory in a man with color-number synaesthesia and Asperger Syndrome. Journal of Consciousness Studies 14, 237-251 (2007).

242. Perini, L. Lisa Perini.

243. Ockelford, A. In the key of genius: The extraordinary life of Derek Paravicini. Arrow Books, London, 2007.

244. Myers, P., Baron-Cohen, S., and Wheelwright, S. An exact mind. Jessica Kingsley, London, 2004.

245. Baron-Cohen, S., Richler, J., Bisarya, D., Gurunathan, N., and Wheelwright, S. The Systemising Quotient (SQ): An investigation of adults with Asperger Syndrome or high-functioning autism and normal sex differences. Philosophical Transactions of the Royal Society 358, 361-374 (2003).

246. Wheelwright, S., Baron-Cohen, S., Goldenfeld, N., Delaney, J., Fine, D., Smith, R., Weil, L., and Wakabayashi, A. Predicting Autism Spectrum Quotient (AQ) from the Systemizing Quotient-Revised (SQ-R) and Empathy Quotient (EQ). Brain Research 1079, 47-56 (2006).

247. Lawson, J., Baron-Cohen, S., and Wheelwright, S. Empathising and systemising in adults with and without Asperger Syndrome. Journal of Autism and Developmental Disorders 34, 301-310 (2004).

248. Baron-Cohen, S. Autism and Asperger Syndrome. Oxford University Press, Oxford, UK, 2008.

249. Fitzgerald, M., and O’Brien, B. Genius genes: How Asperger talents changed the world. Autism Asperger Publishing, Shawnee Mission, KS, 2007.

250. Kanner, L. Autistic disturbance of affective contact. Nervous Child 2, 217-250 (1943).

251. Blastland, M. Joe: The only boy in the world. Profile, London, 2006.

252. Losh, M., and Piven, J. Social cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes. Journal of Child Psychology and Psychiatry 48, 105-112 (2007).

253. Baron-Cohen, S., Ring, H., Chitnis, X., Wheelwright, S., Gregory, L., Williams, S., Brammer, M., and Bullmore, E. fMRI of parents of children with Asperger Syndrome : A pilot study. Brain Cognition 61, 122-130 (2006).

254. Wootton, J. M., Frick, P. J., Shelton, K. K., and Silverthorn, P. Ineffective parenting and childhood conduct problems: The moderating role of callous-unemotional traits. Journal of Consulting and Clinical Psychology 65, 301-308 (1997).

255. Cicchetti, D., Cummings, E. M., Greenberg, M. T., and Marvin, R. S. An organization perspective on attachment beyond infancy. In Attachment in the Preschool Years, ed. M. Greenberg, D. Cicchetti, and M. Cummings. University of Chicago Press, Chicago, 1990, 3-50.

256. Davis, M. H., Luce, C., and Kraus, S. J, The heritability of characteristics associated with dispositional empathy. Journal of Personality and Social Psychology 62, 369-391 (1994).

257. Loehlin, J. C., and Nichols, R. C., Heredity, environment, and personality. University of Texas Press, Austin, 1976.

258. Matthews, K.A., Batson, C. D., Horn, J., and Rosenman, R. H. “Principles in his nature which interest him in the fortune of others … ”: The heritability of empathic concern for others. Journal of Personality and Social Psychology 49, 237-247 (1981).

259. Hughes, C., Jaffee, S. R., Happé, F., Taylor, A., Caspi, A., and Moffitt, T. E. Origins of individual differences in theory of mind: From nature to nurture? Child Development 76, 356-370 (2005).

260. Ronald, A., Happé, F., Price, T. S., Baron-Cohen, S., and Plomin, R. Phenotypic and genetic overlap between autistic traits at the extremes of the general population. Journal of American Academy of Child and Adolescent Psychiatry 45, 1206-1214 (2006).

261. Zahn-Waxler, C., Radke-Yarrow, M., Wagner, E., and Chapman, M. Development of concern for others. Developmental Psychology 28, 126-136 (1992).

262. Knafo, A., Zahn-Waxler, C., Van Hulle, C., Robinson, J. L., and Rhee, S. H. The developmental origins of a disposition toward empathy: Genetic and environmental contributions. Emotion 8, 737-752 (2008).

263. Szatmari, P., Georgiades, S., Duku, E., Zwaigenbaum, L., Goldberg, J., and Bennett, T. Alexithymia in parents of children with autism spectrum disorder. Journal of Autism and Developmental Disorders 38, 1859-1865 (2008).

264. Blonigen, D. M., Carlson, S. R., Krueger, R. F., and Patrick, C. J. A twin study of self-reported psychopathic personality traits. Personality and Individual Differences 35 179-197 (2003).

265. Viding, E., Blair, R. J., Moffitt, T. E., and Plomin, R. Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry 46, 592-597 (2005).

266. Rhee, S. H., and Waldman, I. D. Genetic and environmental influences on antisocial Psychological Bulletin 128, 490-529 (2002).

267. Zanarini, M. C., Williams, A. A., Lewis, R. E., Reich, R. B., Vera, S. C., Marino, M. F., Levin, A., Yong, L., and Frankenburg, F. R. Reported pathological childhood experiences associated with the development of borderline personality disorder. American Journal of Psychiatry 154, 1101-1106 (1997).

268. Links, P. S., Steiner, M., Offord, D. R., and Eppel, A. Characteristics of borderline personality disorder: A Canadian study. Canadian Journal of Psychiatry 33, 336-340 (1988).

269. Soloff, P. H., and Millward, J. W. Developmental histories of borderline patients. Comprehensive Psychiatry 24, 574-588 (1983).

270. Zanarini, M. C., Gunderson, J. G., Marino, M. F., Schwartz, E. O., and Frankenburg, F. R. Childhood experiences of borderline patients. Comprehensive Psychiatry 30, 18-25 (1989).

271. Gunderson, J. G., and Englund, D. W. Characterizing the families of borderlines: A review of the literature. Psychiatric Clinics of North America 4, 159-168 (1981).

272. Zweig-Frank, H., and Paris, J. Parents’ emotional neglect and overprotection according to the recollections of patients with borderline personality disorder. American Journal of Psychiatry 148, 648-651 (1991).

273. Trull, T. J., Sher, K. J., Minks-Brown, C., Durbin, J., and Burr, R. Borderline personality disorder and substance use disorders: A review and integration. Clinical Psychology Review 20, 235-253 (2000).

274. Loranger, A. W., Oldham, J. M., and Tulis, E. H. Familial transmission of DSM-III borderline personality disorder. Archives of General Psychiatry 39, 795-799 (1982).

275. Torgersen, S. Genetics of patients with borderline personality disorder. Psychiatric Clinics of North America 23, 1-9 (2000).

276. Adolphs, R., Spezio, M. L., Parlier, M., and Piven, J. Distinct face-processing strategies in parents of autistic children. Current Biology 18, 1090-1093 (2008).

277. Dorris, L., Espie, C. A. E., Knott, F., and Salt, J. Mindreading difficulties in the siblings of people with Asperger’s Syndrome: Evidence for a genetic influence in the abnormal development of a specific cognitive domain. Journal of Child Psychology and Psychiatry 45, 412-418 (2004).

278. Losh, M., Adolphs, R., Poe, M. D., Couture, S., Penn, D., Baranek, G. T., and Piven, J. Neuropsychological profile of autism and the broad autism phenotype. Archives of General Psychiatry 66, 518-526 (2009).

279. Hoekstra, R., Bartels, M., Hudziak, J., Van Beijsterveldt, T., and Boomsma, D. Genetic and environmental covariation between autistic traits and behavioral problems. Twin Research and Human Genetics 10, 853-860 (2007).

280. Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simmonoff, E., Yuzda, E., and Rutter, M. Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine 25, 63-77 (1995).

281. Folstein, S., and Rutter, M. Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry 18, 297-321 (1977).

282. Bell, C., Abrams, J., and Nutt, D. Tryptophan depletion and its implications for psychiatry. British Journal of Psychiatry 178, 399-405 (2001).

283. Caspi, A., and Silva, P. A. Temperamental qualities at age three predict personality traits in young adulthood: Longitudinal evidence from a birth cohort. Child Development 66, 486-498 (1995).

284. Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., and Poulton, R. Role of genotype in the cycle of violence in maltreated children. Science 297, 851-854 (2002).

285. Buckholtz, J. W., and Meyer-Lindenberg, A. MAOA and the neurogenetic architecture of human aggression. Trends in Neurosciences 31, 120-129 (2008).

286. Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., and Mariri, A., R., Pezawas, L., Blasi, G., Wabnitz, A., Honea, R., Verchinski, B., Callicott, J. H., Egan, M., Mattay, V., and Weinberger, D. R. Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences of the USA 103, 6269-6274 (2006).

287. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., and Weinberger, D. R. A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry 62, 146-152 (2005).

288. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M., and Weinberger, D. R. Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400-403 (2002).

289. Takahashi, H., Takano, H., Kodaka, F., Arakawa, R., Yamada, M., Otsuka, T., Hirano, Y., Kikyo, H., Okubo, Y., Kato, M., Obata, T., Ito, H., and Suhara, T. Contribution of dopamine D1 and D2 receptors to amygdala activity in human. Journal of Neuroscience 30, 3043-3047 (2010).

290. Takahashi, H., Yahata, N., Koeda, M., Takano, A., Asai, K., Suhara, T., and Okubo, Y. Effects of dopaminergic and serotonergic manipulation on emotional processing: A pharmacological fMRI study. Neuroimage 27, 991-1001 (2005).

291. Kempton, M. J., Haldane, M., Jogia, J., Christodoulou, T., Powell, J., Collier, D., Williams, S. C., and Frangou, S. The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: A fMRI study. International Journal of Neuropsychopharmacology 12, 371-381 (2009).

292. Meyer-Lindenberg, A., Kolachana, B., Gold, B., Olsh, A., Nicodemus, K. K., Mattay, V., Dean, M., and Weinberger, D. R. Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans. Molecular Psychiatry 14, 968-975 (2009).

293. Kawagoe, R., Takikawa, Y., and Hikosaka, O. Expectation of reward modulates cognitive signals in the basal ganglia. Nature Neuroscience 1, 411-416 (1998).

294. Schultz, R., Gauthier, I., Klin, A., Fulbright, R. K., Anderson, A., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D., and Gore, J. C. Abnormal ventral temporal cortical activity among individuals with autism and Asperger Syndrome during face discrimination among individuals with autism and Asperger Syndrome. Archives of General Psychiatry 57, 331-340 (2000).

295. Chakrabarti, B., Kent, L., Suckling, J., Bullmore, E. T., and Baron-Cohen, S. Variations in the human cannabinoid receptor (CNR1) gene modulate striatal response to happy faces. European Journal of Neuroscience 23, 1944-1948 (2006).

296. Domschke, K., Dannlowski, U., Ohrmann, P., Lawford, B., Bauer, J., Kugel, H., Heindel, W., Young, R., Morris, P., Arolt, V., Deckert, J., Suslow, T., and Baune, B. T. Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in major depression. European Neuropsychopharmacology 18, 751-759 (2008).

297. Wakabayashi, A., Baron-Cohen, S., and Wheelwright, S. Individual and gender differences in empathizing and systemizing: Measurement of individual differences by the Empathy Quotient (EQ) and the Systemizing Quotient (SQ). Shinrigaku Kenkyu 77, 271-277 (2006).

298. Baron-Cohen, S., Lutchmaya, S., and Knickmeyer, R. Prenatal testosterone in mind: Amniotic fluid studies. MIT/Bradford Books, Cambridge, MA, 2004.

299. Chapman, E., Baron-Cohen, S., Auyeung, B., Knickmeyer, R., Taylor, K., and Hackett, G. Foetal testosterone and empathy: Evidence from the Empathy Quotient (EQ) and the “Reading the Mind in the Eyes” test. Social Neuroscience 1, 135-148 (2006).

300. Young, L. J. and Wang, Z. The neurobiology of pair bonding. Nature Neuroscience 7, 1048-1054 (2004).

301. Donaldson, Z. R., and Young, L. J. Oxytocin, vasopressin, and the neurogenetics of sociality. Science 322, 900-904 (2008).

302. Winslow, J. T., and Insel, T. R. Neuroendocrine basis of social recognition. Current Opinions in Neurobiology 14, 248-253 (2004).

303. Domes, G., Heinrichs, M., Michel, A., Berger, C., and Herpertz, S. C. Oxytocin improves “mind-reading” in humans. Biological Psychiatry 61, 731-733 (2007).

304. Ebstein, R. P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., Riebold, M., Salomon, S., and Yirmiya, N. Arginine, vasopressin, and oxytocin modulate human social behavior. Annals of the New York Academy of Sciences 1167, 87-102 (2009).

305. Zak, P. J., Stanton, A. A., and Ahmadi, S. Oxytocin increases generosity in humans. PLoS One 2, e1128 (2007).

306. Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., and Fehr, E. Oxytocin increases trust in humans. Nature 435, 673-676 (2005).

307. Levine, A., Zagoory-Sharon, O., Feldman, R., and Weller, A. Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment. Peptides 28, 1162-1169 (2007).

308. Chakrabarti, B., Dudbridge, F., Kent, L., Wheelwright, S., Hill-Cawthorne, G., Allison, C., Banerjee-Basu, S., and Baron-Cohen, S. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger Syndrome. Autism Research 2, 157-177 (2009).

309. Jeon, D., Kim, S., Chetana, M., Jo, D., Ruley, H. E., Lin, S. Y., Rabah, D., Kinet, J. P., and Shin, H. S. Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nature Neuroscience13, 482-488 (2010).

310. Mednick, S. A., and Kandel, E. S. Congenital determinants of violence. Bulletin of the American Academy of Psychiatry Law 16, 101-109 (1988).

311. Raine, A. Annotation: The role of prefrontal deficits, low autonomic arousal, and early health factors in the development of antisocial and aggressive behavior in children. Journal of Child Psychology and Psychiatry 43, 417-434 (2002).

312. de Waal, F. The age of empathy: Nature’s lessons for a kinder society. Crown, New York, 2009.

313. de Waal, F., Leimgruber, K., and Greenberg, A. R. Giving is self-rewarding for monkeys. Proceedings of the National Academy of Sciences of the USA 105, 13685-13689 (2008).

314. Mineka, S., Davidson, M., Cook, M., and Keir, R. Observational conditioning of snake fear in rhesus monkeys. Journal of Abnormal Psychology 93, 355-372 (1984).

315. Harlow, H. F., Dodsworth, R. O., and Harlow, M. K. Total social isolation in monkeys. Proceedings of the National Academy of Sciences of the USA 54, 90-97 (1965).

316. Rice, G. E., and Gainer, P. “Altruism” in the albino rat. Journal of Comparative and Physiological Psychology 55, 123-125 (1962).

317. Masserman, J. H., Wechkin, S., and Terris, W. “Altruistic” behavior in rhesus monkeys. American Journal of Psychiatry 121, 584-585 (1964).

318. Daily Telegraph, June 22, 2001.

319. Mitani, J., Watts, D., and Amsler, S. Lethal intergroup aggression leads to territorial expansion in wild chimpanzees. Current Biology 20, R507-508 (2010).

320. Povinelli, D. J. Can animals empathize? Scientific American Presents: Exploring Intelligence 9, 67, 72-75 (1998).

321. Golan, O., Baron-Cohen, S., Wheelwright, S., and Hill, J. J. Systemizing empathy: Teaching adults with Asperger Syndrome to recognize complex emotions using interactive multi-media. Development and Psychopathology 18, 589-615 (2006).

322. Golan, O., Baron-Cohen, S., Ashwin, E., Granader, Y., McClintock, S., Day, K., and Leggett, V. Enhancing emotion recognition in children with autism spectrum conditions: An intervention using animated vehicles with real emotional faces. Journal of Autism and Developmental Disorders 40, 269-279 (2010).

323. Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., and Wasserman, S. Oxytocin increases retention of social cognition in autism. Biological Psychiatry 61, 498-503 (2007).

324. Bateman, A., and Fonagy, P. Mentalization-based treatment for borderline personality disorder: A practical guide. Oxford University Press, Oxford, UK, 2006.

325. Baron-Cohen, S., and Machlis, A. Intense negotiations will not necessarily work: Intense empathy will. Jewish Chronicle, June 4, 2009.

326. Treasure, J. L. Getting beneath the phenotype of anorexia nervosa: The search for viable endophenotypes and genotypes. Canadian Journal of Psychiatry 52, 212-219 (2007).

327. Gillberg, C. The Emanuel Miller Lecture, 1991. Autism and autistic-like conditions : Subclasses among disorders of empathy. Journal of Child Psychology and Psychiatry 33, 813-842 (1992).

328. Daily Mail, September 22, 2009,

329. Arendt, H. Eichmann in Jerusalem: A report on the banality of evil. Penguin, New York, 1963.

330. Haslam, S. A., and Reicher, S. D. Questioning the banality of evil. The Psychologist 21, 16-19 (2008).

331. Asch, S. Opinions and social pressure. Scientific American 193, 31-35 (1955).

332. Milgram, S. Obedience to authority: An experimental view. Harper and Row, New York, 1974.

333. Zimbardo, P., The Lucifer effect: Understanding how good people turn evil. Random House, New York, 2007.

334. Browning, C. R. Ordinary men: Reserve Police Battalion 101 and the final solution in Poland. Penguin, London, 2001.

335. Cesarini, D. Eichmann: His life and crimes. Heinemann, London, 2004.

336. Evans, R. In Hitler’s shadow. Tauris, London, 1989.

337. The Guardian, May 12, 2004.

338. The Guardian, July 18, 2003.

339. Pinker, S. The language instinct. Penguin, London, 1994.

340. Pinker, S. The blank state. Allen Lane Science, London, 2002.

341. Auyeung, B., Baron-Cohen, S., Chapman, E., Knickmeyer, R., Taylor, K., and Hackett, G. Foetal testosterone and the Child Systemizing Quotient (SQ-C). European Journal of Endocrinology 155, 123-130 (2006).

342. Daily Telegraph, March 19, 2009.

343. Slate, April 20, 2004.

344. CNN News, July 28, 2009.

345. Globe and Mail (Ontario), July 29, 2009.

346. Burnett, S., and Blakemore, S. J. The development of adolescent social cognition. Annals of the New York Academy of Sciences 1167, 51-56 (2009).

347. Ashwin, C., Chapman, E., Colle, L., and Baron-Cohen, S. Impaired recognition of negative basic emotions in autism: A test of the amygdala theory. Social Neuroscience 1, 349-363 (2006).

348. Owens, G., Granader, Y., Humphrey, A., and Baron-Cohen, S. LEGO® therapy and the social use of language programme: An evaluation of two social skills interventions for children with high-functioning autism and Asperger Syndrome. Journal of Autism and Developmental Disorders 38, 1944-1957 (2008).

349. BBC Television, December 6, 2009.

350. Time, September 26, 1977.

351. Rifkin, J. The empathic civilization. Tarcher, New York, 2009.

352. Dennett, D. Darwin’s dangerous idea. Simon and Schuster, New York, 1995.